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- In Vitro 3D Cell Culture Modules -

In contrast to other available models of the blood-brain barrier, the DIV-BBB cell culture modules respect the anatomical aspects of the endothelial cell-astrocyte interaction, and allow the formation of tight junctions that can be easily visualized by electron microscope or determined experimentally with the use of tracers. Cell differentiation is also crucially modulated by exposure to shear stress.

In Vitro 3D Cell Culture Modules

Flocel offers a large selection of in vitro 3-dimensional cell culture modules, from single-fiber (left) for on-stage microscopy to multi-fiber (right) for drug trafficking, leukocyte extravasation, monitoring trans-endothelial electrical resistance (TEER), and much more.

For a full outline of the cell culture modules that we offer, and the experimental applications they are compatible with, click here. 

To download an instructional video for preparing the standard Flocel Inc. cell culture module, click here.

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- Products For Sale: 3D Cell Culture Modules -

    

   

PLEASE NOTE: In order to have Flocel products gas sterilized, the customer MUST specify this prior to confirming their purchase. Flocel products are delivered unsterilized and -unless otherwise requested by the customer- must be prepared post-delivery. 

   

  

To receive a quote for the products listed below, check the boxes next to the items of interest, enter your information, and Submit.

For the full list of product offerings, including the different DIV-BBB systems, view the products list on the technology page.

CAR1010:
     - 1.7 inch (4.3 cm) x 19 fiber

Applications:
     - growth of endothelial, epithelial, glial and pericyte cells. 
     - drug permeability and absorption through blood-brain barrier.
     - passage of nanocarriers, viral vectors, DNA, RNA, mRNA, siRNA, etc.
     - vascular dynamics / physiology of arterial and venous blood vessels.
     - effect of mechanical trauma on biological fluid compartments.

CAR1020:
     - 4.5 inch (11.5 cm) x 20 fiber

Applications:
     - growth of endothelial, epithelial, glial and pericyte cells. 
     - drug permeability and absorption through blood-brain barrier.
     - passage of nanocarriers, viral vectors, DNA, RNA, mRNA, siRNA, etc.
     - vascular dynamics / physiology of arterial and venous blood vessels.
     - effect of mechanical trauma on biological fluid compartments.

CAR1030:
     - 1.7 inch (4.3 cm) x 19 fiber
     - transmural openings >10 um


Applications:
     - growth of endothelial, epithelial, glial and pericyte cells. 
     - drug permeability and absorption through blood-brain barrier.
     - passage of nanocarriers, viral vectors, DNA, RNA, mRNA, siRNA, etc.
     - extravasation of leukocytes, stem cells, extracellular vesicles, etc.
     - metastasis of tumor cells between biological compartments.

CAR1040:
   
 - 1.7 inch (4.3 cm) x 19 fiber
     - 5 mm or 8 mm viewing window


Applications:
     - growth of endothelial, epithelial, glial and pericyte cells. 
     - drug permeability and absorption through blood-brain barrier.
     - passage of nanocarriers, viral vectors, DNA, RNA, mRNA, siRNA, etc.
     - microscopic slide mount added for confocal microscopy.

CAR1050:
     - 1.7 inch (4.3 cm) x 19 fiber
     - 5 mm or 8 mm viewing window 
     - transmural openings >10 um


Applications:
     - growth of endothelial, epithelial, glial and pericyte cells. 
     - drug permeability and absorption through blood-brain barrier.
     - passage of nanocarriers, viral vectors, DNA, RNA, mRNA, siRNA, etc.
     - extravasation of leukocytes, stem cells, extracellular vesicles, etc.
     - metastasis of tumor cells between biological compartments.
     - microscopic slide mount added for confocal microscopy.

CAR1060:
     - 1.7 inch (4.3 cm) x 1 fiber
     - piezo micro-pump only


Applications:
     - growth of endothelial, epithelial, glial and pericyte cells. 
     - drug permeability and absorption through blood-brain barrier.
     - passage of nanocarriers, viral vectors, DNA, RNA, mRNA, siRNA, etc.
     - extravasation of leukocytes, stem cells, extracellular vesicles, etc.
     - metastasis of tumor cells between biological compartments.
     - flat fiber enclosure for on-stage microscopy.

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