Personnel

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Ed Rapp
President

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Edward J. Rapp
President

Cleveland Medical Devices Inc.
4415 Euclid Avenue
Cleveland, Oh 44103

Phone: 216.619.5925
Fax: 216.791.6739
Email: erapp@flocel.com


Biography

Mr. Rapp is responsible for the research, development, and marketing of the Dynamic In Vitro Blood-Brain Barrier (DIV-BBB) Model and the operations of Flocel Inc. In addition to his responsibilities at Flocel, he is the Director of Business Development for Cleveland Medical Devices Inc. (CleveMed) where he directs a wide variety of tasks necessary to develop and commercialize cutting edge biomedical innovations. These tasks included the licensing of the DIV-BBB technology from Cleveland Clinic Foundations Innovations. Earlier he was the Director of Engineering where he was the Principal Investigator on five NIH and DOD SBIR programs and oversaw the mechanical, electrical, and software engineering for the company’s products including wireless monitoring devices and more than 17 SBIR programs.

Prior to CleveMed, Mr. Rapp was the President and Founder of North Coast Automation, Inc. (NCA), Cleveland, OH. NCA was an engineering company that specialized in factory automation including motion control and machine vision systems. He directed the evolution of electronic hardware and software libraries from early IBM XT-based machine vision systems through Pentium II, Windows NT. He designed NCA’s original motion controllers, which were installed in hundreds of manufacturing plants from 1981 to 1995.

Mr. Rapp has a BS in Engineering from Case Western Reserve University.

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Damir Janigro, PhD
Scientific Director

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Damir Janigro, Ph.D
Scientific Director

Email: djanigro@flocel.com


Research Activities: Blood Brain Barrier, multiple drug resistance, stroke and cerebrovascular damage, peripehral markers of CNS damage, economic and proeconimic analysis of neurological disorders

Curriculum Vitae

Curriculum:

1976-1982: Graduate student in the dept. of Physiology with Prof. DiFrancesco; voltage clamp investigation of pacemaker activity in the heart. Ph.D., "maxima cum laude"; thesis title: "The pacemaker current in heart Purkinje fibers"
1982-1984: Project Leader at FIDIA Research Laboratories, Abano Terme, Italy. Histological and electrophysiological investigation of CNS neurons following trauma and during recovery.
1983: Visiting Scientist at the Karolinska Institutet, Stockholm. immuno-cytochemistry and HPLC analysis of monoaminergic pathways after neurochemical lesions
1984-1987: Postdoctoral Research Associate at the dept. of Neurosurgery, Univ. of Washington with P.A. Schwartzkroin; electrophysiology of the in vitro hippocampal slice: effects of anoxia
1987-1989: Research Associate in the Depts. of Pharmacology and Physiology at the University of Milan
1990-1995: Research Assistant Professor at the Dept. of Neurosurgery, Univ. of Washington;
1993-1995: Research Assistant Professor (Adjunct), Dept. of Environmental Health, University of Washington;
1996-present Associate Professor of Neurological Surgery and Environmental Health
1996-present Adjunct (Contract) Professor of Physiology, University of Milan, Italy
1998-2001: Contract Professor, University of Pisa, Pisa, Italy (May 1998)
1999-2015: Staff, Cleveland Clinic Foundation, Cleveland, OH
1999-2015: Director, Cerebrovascular Research, Dept. of Neurosurgery, Cleveland Clinic Foundation
1999-present: Affiliate Professor, Neurosurgery, University of Washington (Honorary title)
2003-2015: Professor of Molecular Medicine, Cleveland Clinic Lerner College of Medicine

2002-present: Scientific Director, Flocel, Inc.

Honors

1993: American Heart Association Young Investigator Award, Boston, MA
1994-present: Member, Scientific Council, American Heart Association (National)
1997: Burroughs Welcome Research Travel Grant (London, UK)
1997: Associate Member, European Blood-brain Barrier Consortium (King's College, London, UK)
2001: Organizing Committee Cerebrovascular Biology Meeting, Cambridge, UK
2001: NIH-NINDS Study Section NCD-II, Ad hoc
2001: NIH-NIAAA Study Section ZAAS, Member
2002-present: Leadership Group, CCF Cerebrovascular Research Programmatic Research
2002-present: CCF Lerner College of Medicine Medical School Curriculum Development
2002-present: NIH-NINDS Study Section NCD-II, Member
2004: NIH Roadmap Review Group
2005-2010: NIH BINP Study section Member
2013-present: Member, Neurobiology Commission, International League Against Epilepsy

Patents

US 6,667,172 Cell and tissue culture modeling device and apparatus and methods of using the same (Issued Dec 2003)
US 09/957,023 A peripheral marker of blood-brain barrier permeability (Issued December, 2004)
US 20040009581 Markers of blood barrier disruption and methods of using same (Issued July 2001)
PCT/US2015/020561 DIAGNOSTIC MARKER FOR TREATMENT OF CEREBRAL ISCHEMIA Filed 2015
PCT/US12/37170 SERUM S100B AND USES THEREOF PCT Filed 2012

Consulting

2012-2015: Consultant for Shimojani, Inc.
2010-2012: Consultant for Numoda
2007: Consultant for Fonds de Solidarité de la FTQ 545, Montreal, CA
2006 -2011 Consultant for the Seattle Neuroscience Institute, Swedish Hospital. Seattle, WA;
2000- 2004: Consultant for IRB Italy
2000- 2004: Consultant for Sangtec, Inc. Sweden
1999-2000: Consultant for FiberCell, Inc.
1998-1999: Consultant for Berlex, Richmond, CA
1998-1999: Consultant for Epix Medical, Cambridge, MA
1997-1999: Consultant for Hedral Therapeutics, Portland, OR
1996-1998: Consultant for Prof. Jay Nelson, OHSU on Blood-brain barrier and HIV
1996-1997: Consultant for Parke-Davis, Ann Arbor, MI
1997-1999: Consultant for Biosupport, Inc., Redmond, WA,
1995-1997: Consultant on blood-brain barrier models for Cellco Inc., Germantown, MD

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Robert Schmidt
Chairman of the Board

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Robert N. Schmidt, MBA, JD
Chairman of the Board

Cleveland Medical Devices Inc.
4415 Euclid Avenue
Cleveland, Oh 44103

Phone: 216.619.5925
Fax: 216.791.6744
Email:rschmidt@flocel.com


Biography

Mr. Robert N. Schmidt is the founder and president of Cleveland Medical Devices Inc. and chairman of Orbital Research Inc., both of which were started in 1990. He received his BS degree in Mechanical Engineering (70) and his MS (71) from Rensselaer Polytechnic Institute in Troy, NY; his MBA (75) from the University of Utah, and his Juris Doctor (80) from Cleveland State University. He is a licensed professional engineer (Ohio, 76) and an attorney (Ohio, 81 and US Patent and Trademark Office, 82).

Both Cleveland Medical Devices and Orbital Research have experienced extraordinary growth over the last decade; both being named to the Inc. 500 list, and both being on NE Ohio's Weatherhead 100 list four times. Mr. Schmidt is the only person in America to have two companies named on the Inc. Inner City 100 list, and both companies have made the list three years in a row. Both companies have been bootstrapped with sales generated funding, and the companies have no debt. He is on the Inc. 500 Advisory Board.

Both Mr. Schmidt and his companies have also been recognized for their innovative technologies: Cleveland Medical Devices has received the NORTECH/EDI Innovation Award four times, and Orbital Research has received this award twice. As a principal investigator, Mr. Schmidt has supervised programs for the US Army, Navy, and Air Force, DARPA, the National Institutes of Health, NASA, Dept. of Education, Dept. of Transportation, and the National Science Foundation. The companies have performed over $30 million of research for the US Government.

Prior to starting his companies, Mr. Schmidt was a consultant to the Center for Materials for Space Structures, a NASA Center at Case Western Reserve University. He coordinated materials space flight experiments to fly on the Space Shuttle and on the Wakeshield, evaluating the effects of atomic oxygen and the low earth environment on lighter weight polymers and "self-healing" materials. From 1984 to 1990, Mr. Schmidt served as Director of Technology and Program Development at Life Systems, Inc. He managed Functional Electrical Stimulation (FES) programs, helping paraplegics to walk, and other medical programs; an "Advanced Collective Protection Chemical Defense System," and several other Army chemical defense programs; and the "Zero-Gravity Shower" program and several other hygiene and regenerable life support programs for the Space Station Freedom; as well as water recycling and electrolysis programs.

From 1976 to 1983, Mr. Schmidt was Manager of Licensing and Technology Development, a Project Control Manager, and a Project Engineer for Davy McKee Corporation. He was responsible for technology transfer for the 4,000-person engineering firm. As the project engineer for three petrochemical plants, he directed engineering efforts and controlled programs worth up to $200 million for ARCO, Exxon, and Shell Oil. He was the chief engineer for the design of the world's largest single train methanol plant, and built a coal liquifaction plant for Exxon. From 1972 to 1976, he was Chief of Engineering Plans for the U.S. Army Corps of Engineers in Stuttgart, West Germany, managing engineering efforts at 48 U.S. Military installations in southern Germany supervising over 800 projects.

Mr. Schmidt has received the Edison Biotechnology Center Award for Outstanding Contribution to Biotechnology in Ohio in 1993, is a Founding member of the FES Society, and a member of the AIAA, SAE, AAMI, and IEEE. He has published over 30 papers, and has 17 US patents in the areas of flight control, radio design, electrophysiology, pressure sore prevention, chemical defense, and Braille displays.

In his newest ventures, Mr. Schmidt serves as the Chairman of several other companies including iACTIV Corporation and ComSense Technology Inc., both MEMS companies; and of RadioStorm Inc., CleveMed NeuroWave Inc. and Flocel Inc. He is also the founder of the Americas' Arts and Sciences Foundation, of the Ohio MEMS Association and of NEOBio; and an angel investor in several non-related Cleveland area companies. He is on the Federal Reserve Bank of Cleveland Business Advisory Council, and has been the Keynote speaker for the Society of Manufacturing Engineers and an invited Speaker to the American Institute for Medical and Biological Engineering.

Two of Mr. Schmidt's companies, the Ohio MEMS Association and NEOBio were recognized by the Cleveland Innovations Lab as local innovators and were awarded monetary grants to continue their efforts in the community.

Mr. Schmidt has been organizing community programs and discussions to bring the topics of Healthcare business growth and job creation to the forefront. In October, 2004, he arranged for The Honorable Claude A. Allen, Deputy Secretary of Health and Human Services, and Leslie V. Norwalk, Deputy Administrator of the Centers for Medicare & Medicaid Services, to come to Cleveland to present their views on the future of Healthcare in the United States.

 

Who We Are

Flocel Inc. consists of a team of entrepreneurs, scientists and engineers that have distinguished themselves in their respective fields. These biographies are of the current personnel of Flocel. Some of these biographies also provide a list of published writings/articles and projects.