- In Vitro 3D Cell Culture: An Overview -
Each year pharmaceutical companies spend millions of dollars to test drugs using in vitro models of the blood-brain barrier (BBB). Flocel’s family of Dynamic In Vitro Blood-Brain Barrier (DIV-BBB) products offer a superior approach to this method by utilizing human endothelial cells and formation of tight junctions within its dynamic system, resulting in a physiologically accurate reflection of BBB characteristics.
The DIV-BBB 2.0 enables more accurate pharmacokinetic and toxicological studies and reflects in vivo blood-brain barrier properties. Its replication of important endothelial cell-astrocyte interactions and ability to sustain up to four cell culture modules substantially reduces drug development cost and experimental time. In addition to the cerebrovascular system, the cell culture modules allow for pericyte, epithelial and tumor cell growth, as well as modeling of bone marrow, the placental barrier, the blood-CSF barrier, and much more!